The Book of Skulls is a third-person mystery/action/adventure set in Auld Reekie, an alternative 19th C Edinburgh.
Although student doctor Liz is the cleverest student in her class she cannot graduate because she is a woman. A mysterious woman Dr Lex, tells Liz that she will persuade the medical board to let her graduate, if she can help the police to identify a headless corpse found in Greyfriars Kirkyard. When further mutilated bodies turn up Liz’s mission develops into finding out who or what is responsible. Over the course of the game the protagonist discovers clues which seem to lead to phrenology obsessed antagonist. But all is not what it seems… is the killer even human?